Pierre-Emerick Aubameyang was handed a first start for Barcelona as Napoli arrived at Camp Nou on Thursday.
For the Europa League play-off first leg, former Arsenal striker Aubameyang was selected along with Ferran Torres and Adama Traore in a three-man frontline.
All three recently left the Premier League behind to join Barcelona, with former Manchester City man Torres and ex-Wolves forward Traore having already started for Xavi s team.
Aubameyang was named to start a first-team game at club level for the first time since he lined up for Arsenal against Manchester United on December 2.
He fell out of favour at Arsenal as his relationship with manager Mikel Arteta disintegrated, leading to the new start in Spain.
Head coach Xavi said of the Gabon striker on Wednesday: I am very happy with him. He is very professional and very positive within the group.
Sergio Busquets and Gavi were rested to the bench as head coach Xavi made use of his squad, while there was a notable presence in the Napoli side as Victor Osimhen was passed fit.
The Nigeria striker did not train on Monday due to a minor knee problem but was given the green light to line up for Luciano Spalletti s team.
Barça XI
— FC Barcelona (@FCBarcelona)
This was a clash of two of Diego Maradona s former clubs, who were vying for a place in the Europa League last-16 stage.
The only previous meeting between the teams in a major European competition occurred in the last 16 of the 2019-20 Champions League, when Barcelona won 4-2 on aggregate after a 3-1 win at Camp Nou.